| 摘要 |
A pharmaceutical composition comprising a polydeoxyribonucleotide of random sequence formula is disclosed, andPv, (dAp)w, (dGp)x, (dTp)y, (dCp)zwherein Pv is 1-5 phosphoric radicals, (dAp)w is 12-24 deoxyadenylic monomers, (dGp)x is 10-20 deoxyguanylic monomers, (dTp)y is 13-26 deoxythymidylic monomers, and (dCp)z is 10-20 deoxycytidylic monomers; wherein the polydeoxyribonucleotide has: a homogenous anodic mobility in electrophoresis, an extinction coefficient E1%1 cm at 260+/-1 nm=220+/-10, an extinction coefficient E230/E260=0.45+/-0.04, a molar extinction coefficient (referred to phosphorous), epsilon (P)=7750+/-500, a rotary power [ alpha ]20 DEG D=53 DEG +/-6, and a reversible hyperchromicity as percent in native DNA h=15+/-5, in combination with a pharmaceutically acceptable carrier or diluent. A method of treating or preventing a diabetic neuropathy using the polydeoxyribonucleotide is also shown.
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