发明名称 |
METHOD FOR THE PRODUCTION OF ACTIVATED MARKED TUMOR-SPECIFIC T CELLS AND USE THEREOF IN TREATMENT OF TUMORS |
摘要 |
A method for the production of activated tumor-specific T cells by co-cultivating, ex vivo, tumor cells from a patient with T cells from that patient, comprising the steps of: i) incubating the tumor cells with a first fusion protein obtained from a B7 protein and one partner of a biological binding pair and a second fusion protein obtained from an antibody against a cell surface antigen and the other partner of the biological binding pair; ii) inhibiting the proliferation of the tumor cells prior to or after that incubation; iii) co-cultivating the tumor cells with the T cells to be activated, until activation of the T cells is attained; iv) separating the activated T cells from the tumor cells, is highly efficient and can be carried out in a simple manner.
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申请公布号 |
WO9737004(A1) |
申请公布日期 |
1997.10.09 |
申请号 |
WO1997EP01541 |
申请日期 |
1997.03.26 |
申请人 |
BOEHRINGER MANNHEIM GMBH;CASORATI, GIULIA;DELLABONA, PAOLO |
发明人 |
CASORATI, GIULIA;DELLABONA, PAOLO |
分类号 |
A61K35/14;A61K39/00;C12N5/0783;(IPC1-7):C12N5/08 |
主分类号 |
A61K35/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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