Methods to identify hemochromatosis

摘要

The present invention provides methods to identify hemochromatosis in an individual. For example, the invention provides a method of detecting reduced association of beta 2-microglobulin with a nonclassical MHC class I heavy chain molecule or a mutation in nonclassical MHC class I heavy chain-encoding DNA which results in a reduction of beta 2-microglobulin-heavy chain association indicating that the individual tested has or is at risk of having hemochromatosis.