8-substituted styryl xanthine derivatives

摘要

Disclosed are xanthine derivatives represented by the following Formula (I): <IMAGE> (I) in which R1, R2, and R3 independently represent hydrogen or lower alkyl; Q1, Q2, and Q3 independently represent hydrogen, lower alkyl, lower alkoxy, or halogen; and X represents -COR4 (in which R4 represents hydrogen, hydroxy, lower alkyl, or lower alkoxy) or -SO2R5 {in which R5 represents hydroxy, lower alkoxy, trifluoromethyl, <IMAGE> in which R6 and R7 independently represent hydrogen, hydroxy-substituted or unsubstituted lower alkyl, aryl, or <IMAGE> (in which m represents an integer of 1 to 3; and R8 and R9 independently represent hydrogen or lower alkyl), or <IMAGE> (in which Y represents a single bond, oxygen, or N-R10 in which R10 represents hydrogen or lower alkyl; and n1 and n2 independently represent an integer of 1 to 3)}, and pharmaceutically acceptable salts thereof.