发明名称 |
Human recombinant collagen in the milk of transgenic animals |
摘要 |
Production of human procollagen or collagen in cells which ordinarily do not produce these molecules is effected by constructing expression systems compatible with mammary glands of non-human mammals. For example, expression systems can be microinjected into fertilized oocytes and reimplanted in foster mothers and carried to term in order to obtain transgenic non-human mammals capable of producing milk containing recombinant human procollagen or collagen. Human procollagen or collagen produced in this manner can be made of a single collagen type uncontaminated by other human or non-human collagens.
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申请公布号 |
US5667839(A) |
申请公布日期 |
1997.09.16 |
申请号 |
US19940183648 |
申请日期 |
1994.01.18 |
申请人 |
COLLAGEN CORPORATION |
发明人 |
BERG, RICHARD A. |
分类号 |
A01K67/027;A23C9/152;A23C9/20;A23J1/00;A23J1/20;A23J3/06;C07H21/04;C07K14/78;C12N5/10;C12N15/09;C12N15/85;C12P21/02;(IPC1-7):A23C9/152;C07K1/00;C12N15/06 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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