SUBSTITUTED PHENYLOXAZOLIDINONES AND THEIR USE AS ANTIBIOTICS

摘要

The invention concerns a compound of formula (I) wherein, for example: R<1> is hydroxy, chloro, fluoro, amino, azido, of the for mula -NHC(=O)R wherein R is hydrogen or (1-4C)alkyl, of the formula -N(Me)C(=O)R wherein R is hydrogen, methyl or methoxy or of the formula -NHS(O)n(1-4C)alkyl wherein n is 0, 1 or 2; R<2> and R<3> are independently hydrogen or fluoro; R<4>, R<5> and R<6> are independently selected from hydrogen, (1-4C)alkyl (optionally substituted), halo, trifluoromethyl, carboxy, (1-4C)alkoxycarbonyl, carbamoyl, N-(1-4C)alkylcarbamoyl, di-(N-(1-4C)alkyl)carbamoyl, cyano or nitro; and pharmaceutically acceptable salts thereof; and in particular the compounds N-[(5S)-(3-(4-(4-bromoimidazol-1-yl)-3-fluorophenyl)-2-oxooxazolidin-5-ylmethyl]acetamide and N-[(5S)-(3-(4-(4-cyanoimidazol-1-yl)-3-fluorophenyl)-2-oxooxazolidin-5-ylmethyl]acetamide and pharmaceutically acceptable salts thereof; processes for their preparation; pharmaceutical compositions containing them and their use as antibacterial agents.