发明名称 |
QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS |
摘要 |
The invention concerns quinazoline derivatives of formula (I), wherein X1 is a direct link or a group such as CO, C(R2)2 and CH(OR2); wherein Q1 is phenyl, naphthyl or a 5- or 6-membered heteroaryl moiety and Q1 optionally bears up to 3 substituents; wherein m is 1 or 2 and each R1 may be a group such as hydrogen, halogeno and trifluoromethyl; and wherein Q2 may be phenyl or a 9or 10-membered bicyclic heterocyclic moiety and Q2 optionally bears up to 3 substituents; or a pharmaceutically acceptable salt thereof; processes for their preparation, pharmaceutical compositions containing them and the use of their receptor tyrosine kinase inhibitory properties in the treatment of proliferative disease such as cancer.
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申请公布号 |
CA2242102(A1) |
申请公布日期 |
1997.08.21 |
申请号 |
CA19972242102 |
申请日期 |
1997.02.10 |
申请人 |
ZENECA LIMITED |
发明人 |
JOHNSTONE, CRAIG;BARKER, ANDREW JOHN |
分类号 |
C07D239/94;C07D401/04;C07D401/12;C07D403/04;C07D403/12;C07D405/04;C07D405/12;C07D409/04;C07D409/12;C07D413/04;C07D413/12;C07D413/14;C07D521/00;(IPC1-7):C07D239/94;C07D401/00;C07D403/00;C07D405/00;C07D409/00;C07D413/00;C07D417/00;C07D471/04;A61K31/505;A61K31/535;A61K31/54 |
主分类号 |
C07D239/94 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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