| 摘要 |
Imidazopyridine compounds of formula (I) and their salts and oxides of the pyridine are new. R0 = 1-4C alkyl, CH2OH or CF3; R1 = 1-4C alkyl; R2, R4 = H, 1-4C alkyl, 1-4C alkoxy, halo or CF3; R3 = SO2R6, CO-R7, COO-R8 or CON(R9)R1-0; R5 = H, 1-4C alkyl, 1-4C alkoxy or halo; A = O or NH; R6 = 1-4C alkyl (optionally substituted by S(O)n-R19 or Ar or partly or completely substituted by F), Ar, CqH(2q-2)-aryl, or optionally OH-substituted thiolane (or its oxide or dioxide); Ar = aryl (optionally substituted by R16, R17 and R18); R7 = Ar or 1-4C alkyl substituted by Ar; R8 = Me (optionally substituted by R12), 2-4 C alkyl (optionally substituted by R11, R12 or R15), -N=C(R13)R14, Ar or -CqH(2q+1); R9 = H or 1-4C alkyl; R10 = R11-substituted 2-4C alkyl or 1-4C alkyl optionally substituted by R12; R11 = 1-4C alkoxy, 1-4C alkylcarbonyloxy, OH, hydroxy-(2-4C alkoxy) or 1-4C alkoxy-(1-4C alkoxy); R12 = 1-4C alkoxycarbonyl, 1-4C alkylcarbonyl, COOH, mono- or di(1-4C alkyl)aminocarbonyl, thienyl, pyridyl, or Ar; R13, R14 = 1-4C alkyl, phenyl or phenyl-(1-4C alkyl); or R13+R14 = 4-6C alkylene; R15 = phthalimidyl or S(O)a-R19; R16 = H, halo, NO2, 1-4C alkyl, 1-4C alkoxy (optionally fully or partially substituted by F), CF3, OH, COOH, 1-4C alkoxycarbonyl, CN, phenyl, benzoyl, mono- or di-(1-4C alkyl)amino, NH2, 1-4C alkylcarbonylamino or S(O)a-R19; R17 = H, halo, 1-4C alkoxy, NO2, COOH, 1-4C alkyl or OH; R18 = H or halo; R19 = 1-4C alkyl; n = 0-2; q = 2 or 3. |
