发明名称 |
Thiophene compounds, process for their preparation and pharmaceutical compositions containing them |
摘要 |
<p>1-(R1)-2-(R2)-3-(R3)-4-Methyl-thiophene derivatives of formula (I) and their salts are new. one of R1, R2 or R3 = -(CH2)m-Ph (ring substituted by X); another R1, R2 or R3 = -(CH2)a-C(H)2-n(CH3)n-(CH2)b-N(Ra)(Rb); and the third R1, R2 or R3 = H or methyl; m = 2-6; X = H, 1-5C alkyl or alkoxy or di(1-5C)alkylamino; n = 0-2; a = 2 or 3; b = 1 or 2, such that (a+b) = 4; Ra+Rb = H or 1-5C alkyl; or NRaRb = 5- or 6-membered heterocycle which may also contain O or a second N atom which may be substituted by 1-5C alkyl or ar(1-5C)alkyl, the aryl part being mono- or poly- substituted by halo, 1-5C alkyl or 1-5C alkoxy).</p> |
申请公布号 |
EP0780387(A1) |
申请公布日期 |
1997.06.25 |
申请号 |
EP19960402660 |
申请日期 |
1996.12.09 |
申请人 |
ADIR ET COMPAGNIE |
发明人 |
WIERZBICKI, MICHEL;SAUVEUR, FREDERIC;BOUSSARD, MARIE-FRANCOISE;BONNET, JACQUELINE;SABATINI, MASSIMO |
分类号 |
A61P3/00;A61K31/495;A61K31/535;A61P19/10;A61P43/00;C07D333/20;(IPC1-7):C07D333/20;A61K31/38 |
主分类号 |
A61P3/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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