发明名称 |
Bcl-2-associated proteins |
摘要 |
The present invention provides nucleotide sequences encoding proteins and fragments thereof that bind to Bcl-2-related proteins. The invention also provides a Bcl-2-associated protein (BAP) such as Bcl-2-associated protein-1 (BAP-1), which binds to Bcl-2. The invention also provides antibodies that specifically bind to a BAP. The invention further provides methods for detecting agents such as drugs that alter the binding of a BAP such as BAP-1 or Raf-related protein with a Bcl-2-related protein and methods for detecting agents that induce dissociation of a bound complex formed by the association of a BAP and a Bcl-2-related protein. The invention further provides methods for modulating the activity of a Bcl-2-related protein in a cell by introducing into the cell a nucleic acid encoding a BAP or by introducing into the cell an antisense nucleotide sequence, which is complementary to a region of a gene encoding a BAP.
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申请公布号 |
US5641866(A) |
申请公布日期 |
1997.06.24 |
申请号 |
US19950463089 |
申请日期 |
1995.06.05 |
申请人 |
LA JOLLA CANCER RESEARCH FOUNDATION |
发明人 |
REED, JOHN C.;TAKAYAMA, SHINICHI;SATO, TAKAAKI |
分类号 |
G01N33/53;A61K38/00;C07K14/47;C07K14/82;C07K16/18;C12N15/09;C12P21/02;C12P21/08;C12Q1/02;G01N33/566;(IPC1-7):C07K16/00;G01N33/574 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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