| 摘要 |
A long lasting treatment for dry eye syndrome which imparts superior water retention and comfort to the eye for time periods greater than one hour has been developed based on polyoxyethylene-polyoxypropylene block copolymers (referred to herein as poloxamers). The compositions can be used for drug delivery. The preferred composition is isotomic. The polymer is added to an isotomic aqueous solution to form a concentration between 1 % and 35 %, most preferably 16 % to 25 %. The preferred polyoxyethylene-polyoxypropylene block copolymers have a sol-gel transition dependent on the concentration of the polymer and transform to a solid, clear gel having excellent optical properties at a temperature of 25 DEG C, and significantly increase in viscosity at the temperature of the eye.
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