SYNTHETIC OLIGOPEPTIDES SHOWING CAPABILITY TO INTERACT SPECIFICALLY WITH ANTIBODIES RAISED TO HEPATITIS C VIRUS AND METHODS OF HEPATITIS C DIAGNOSIS USING THESE PEPTIDES

摘要

FIELD: medicine, molecular biology, virology. SUBSTANCE: invention relates to biologically active compounds - synthetic oligopeptides corresponding to amino acid residues 1711-1732 and 1921-1940 of nonstructural protein 4 (NS4) of hepatitis C virus (HCV) showing capability to interact specifically with antibodies to HCV, and methods of hepatitis C diagnosis using these oligopeptides. Synthetic oligopeptides corresponding to amino acid residues 1711-1732 and 1921-1940 of protein NS4 HCV can be used separately as specific antigens for detection of antibodies to hepatitis C virus in human sera and as complementary antigens for enhancement of sensitivity of the known test-systems to hepatitis C. Use of synthetic oligopeptides corresponding to amino acid residues 1711-1732 and 1921-1940 of protein NS4 HCV as complementary antigens in test-system based on recombinant complete nucleocapside protein HCV increases effectiveness of screening of antibodies to hepatitis C virus. EFFECT: higher efficiency.