HIGH EFFICIENCY TISSUE SPECIFIC COMPOUND DELIVERY SYSTEM USING STREPTAVIDIN-PROTEIN A FUSION PROTEIN

摘要

The invention relates to a method of delivering toxins or nucleic acids into specific cell types and to the complexes for the practice of the method. According to the invention, an antibody that recognizes a cell surface antigen is non-covalently bound to the antibody binding site of a ST-PA fusion protein; a biotinylated toxin or nucleic acid is bound to the biotin-binding site. In an alternative embodiment, the toxin or nucleic acid can be bound to a third biotinylated molecule, an adapter, which is bound to the biotin-binding site.