发明名称 |
Method for the isolation and purification of vitamin K-dependent proteins |
摘要 |
A method for the separation of vitamin K-dependent proteins from non-vitamin K-dependent accompanying proteins is described wherein the method is characterized in that at least anion exchange chromatography and optionally affinity chromatography is carried out as well. The method is suitable especially for the purification of Factor II, VII, IX, X as well as Protein S, Protein C and Protein Z. With the aid of the method according to the invention a vitamin K-dependent protein is obtained which is present at a purity of 95%.
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申请公布号 |
US5633350(A) |
申请公布日期 |
1997.05.27 |
申请号 |
US19950394508 |
申请日期 |
1995.02.27 |
申请人 |
IMMUNO AKTIENGESELLSCHAFT |
发明人 |
FISCHER, BERNHARD;MITTERER, ARTUR;DORNER, FRIEDRICH |
分类号 |
A61K38/43;A61P7/04;C07K1/14;C07K1/16;C07K1/18;C07K1/22;C07K14/47;C07K14/745;C12N9/64;C12N9/74;(IPC1-7):A61K35/14 |
主分类号 |
A61K38/43 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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