发明名称 |
Inhibition of expression of beta-lactamase using esters of fatty acid alcohols |
摘要 |
A class of chemical compounds comprising fatty acid ester derivatives used to inhibit beta-lactamase production by infectious bacteria. These inhibitors have been found to retard the resistance of certain strains of bacteria to beta-lactam antibiotics, such as penicillin, by interfering with the transcription of the beta-lactamase gene and precluding expression of beta-lactamase. In accordance therewith, these inhibitors permit effective treatment of infections of otherwise resistive bacteria with antibiotics.
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申请公布号 |
US5633245(A) |
申请公布日期 |
1997.05.27 |
申请号 |
US19950470997 |
申请日期 |
1995.06.06 |
申请人 |
PUBLIC HEALTH RESEARCH INSTITUTE |
发明人 |
BROWN-SKROBOT, SUSAN;NOVICK, RICHARD P.;PROJAN, STEVEN J. |
分类号 |
A61K31/23;A61K31/43;A61K31/545;(IPC1-7):A61K31/545;A61K31/22;A61K31/225;A61K31/20 |
主分类号 |
A61K31/23 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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