摘要 |
N-(Aryloxy or aryloxyimino)cycloalkylenyl-N-hydroxyurea derivs. of formula (I), their salts and prodrugs, are new: Ar = phenyl, naphthyl, or biphenyl (all opt. substd. by 1-3 1-4C alkyl, haloalkyl, hydroxyalkyl, alkoxy, haloalkoxy, or alkylthio, 2-4C alkoxyalkoxy, OH, halo, CN, NH2, mono- or di-(1-4C alky)amino, 2-6C alkanoylamino, COOH, 2-6C alkoxycarbonyl, or phenyl, phenoxy, phenylthio, or phenylsulphinyl (all opt. substd. by 1-3 Q) or furyl, benzo(b)furyl, thienyl, benzo(b)thienyl, pyridyl, or quinolyl (all opt. substd. by 1-3 1-4C alkyl, haloalkyl, or alkoxy, halo,OH, or phenyl, phenoxy or phenylthio (all opt. substd. by 1-3 Q)); Q = 1-4C alkyl, haloalkyl, alkoxy, or haloalkoxy, cyano or halo; X = 1-4C alkylene, 2-4C alkenylene, (CHR1)mQ1(CHR2)n, O(CHR1)jQ2; or (CHR1)ON= (with the N attached to cycloalkene ring); Q1 = O, S, SO, SO2, NR3, CH=NO, or CO, Q2 = O, S, SO, SO2, or NR3; R1-R3, Z = H or 1-4C alkyl; m, n = 0-4; j = 1-4; p = 1 or 2; Y = H, or 1-4C alkyl, haloalkyl, alkoxy, or alkylthio, 2-4C alkoxyalkyl, OH, halo, CN, or NH2; and M = H, a cation, or a metabolically cleavable gp. |