<p>A red blood cell surrogate which is composed of a nanocrystalline core particle to which an oxygen carrier such as hemoglobin is bound. An oxygen carrier anchor coating is provided between the nanocrystalline core particle and the oxygen carrier in order to provide binding of the oxygen carrier to the nanocrystalline core particle without denaturing the oxygen carrier or otherwise destroying its oxygen carrying capacity. The nanocrystalline core particle with the oxygen carrier bound thereto is coated with a layer of lipid and then an outer layer of a sugar or allosteric effector is applied.</p>
申请公布号
EP0758226(A4)
申请公布日期
1997.05.07
申请号
EP19950917631
申请日期
1995.04.21
申请人
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人
KOSSOVSKY, NIR;GELMAN, ANDREW, E.;HNATYSZYN, H., JAMES