| 发明名称 |
RECOMBINANT VIRUSES CONTAINING MOBILE GENETIC ELEMENTS AND METHODS OF USE IN GENE THERAPY |
| 摘要 |
Recombinant E1-deleted adenoviruses are provided that contain a transgene associated with the elements of a recombinant transposon sequence, e.g., from Moloney murine leukemia virus (Mo-MLV), necessary to achieve specific retrotransposition of the transgene from the recombinant adenovirus into the target cell chromatin. Also provided are methods for generating the recombinant adenoviruses and methods of use thereof.
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| 申请公布号 |
WO9715679(A1) |
申请公布日期 |
1997.05.01 |
| 申请号 |
WO1996US17176 |
申请日期 |
1996.10.24 |
| 申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;KELLEY, WILLIAM, MARK;WILSON, JAMES, M. |
发明人 |
KELLEY, WILLIAM, MARK;WILSON, JAMES, M. |
| 分类号 |
C07K14/16;C12N15/00;C12N15/861;C12N15/867;C12N15/90;(IPC1-7):C12N15/86;A61K48/00;C12N5/10 |
主分类号 |
C07K14/16 |
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