A BINARY CODING METHOD FOR USE IN COMBINATORIAL CHEMISTRY

摘要

The present invention is to a technique for labeling a ligand or compounds covalently bound to solid-phase-synthesis resin with a tag containing <13>C and/or <15>N. This tagging along with high-resolution isotope filtered <1>H NMR, and Magic Angle Spinning probes provides for a technique which is general, nondestructive, and leaves the resin-bound sample intact and available for further chemical transformations. The limit of detection (< 800 pmol) in this system is sufficient to allow NMR to be used in deciphering the contents of a "one-bead, one-compound" combinatorial chemistry library.