| 摘要 |
A process for the preparation of alpha -chloromethylphenylacetic acid derivatives of formula (I), wherein X is a radical inert towards the reaction; m is from 0 to 4; Z is a group (a), (b), (c) or (d); R3 is CH3, CH2F or CHF2; R4 is C1-C6alkyl; R5 is hydrogen or C1-C4alkyl; n is 0 or 1; which process comprises reacting a tert-benzylamine of formula (II), wherein X, m and Z are as defined for formula (I) and R1 and R2 are each independently of the other C1-C6alkyl, C1-C6alkenyl, C1-C6alkoxyalkyl, C3-C6cycloalkyl or unsubstituted or substituted benzyl, or R1 and R2 together with the nitrogen atom are an unsubstituted or substituted 6- or 7-membered ring that in addition to the nitrogen atom may also contain a further hetero atom O, S or N, with a chloroformic acid ester or phosgene in the absence of water. The compounds of formula (I) are important intermediates for the preparation of microbicides. |
