摘要 |
A DNA fragment or a restriction enzyme-digested DNA fragment, the DNA fragment containing a gene, acyA, encoding a 3-acylation enzyme for macrolide antibiotics, characterized by being derived from a strain belonging to the genus Streptomyces, having a size of about 1.8 kb or about 3.2 kb, and having a DNA base sequence shown in a restriction enzyme map shown in Fig. 1(A) or Fig. 1(B), respectively, in the attached drawing. 3-Acylated macrolide antibiotics can be produced advantageously using macrolide antibiotics-producing bacteria transformed with vector plasmids having inserted therein the DNA fragment. |
申请人 |
MERCIAN CORP., TOKIO/TOKYO, JP |
发明人 |
ARISAWA, AKIRA, FUJISAWA-SHI, KANAGAWA-KEN, JP;KAWAMURA, NAOTO, YAMATO-SHI, KANAGAWA-KEN, JP;KOJIMA, IKUO, KAWASAKI-SHI, KANAGAWA-KEN, JP;TONE, HIROSCHI, YOKOHAMA-SHI, KANAGAWA-KEN, JP;OKAMOTO, ROKURO, FUJISAWA-SHI, KANAGAWA-KEN, JP;OKAMURA, KAZUHIKO, KANAGAWA-KEN, JP |