| 摘要 |
<p>Hitherto unknown compounds of formula (II) wherein R1 is hydrogen or methyl; R2 is hydrogen, methyl, CH¿2?OH, CH2OR?3¿, CHO, CH=CH¿2?, COOH or COOR?4; R3¿ is alkyl, aralkyl, aryl, alkanesulfonyl, arene-sulfonyl; alkanoyl or aroyl, optionally substituted; R4 is alkyl, alkenyl, alkynyl, aralkyl, aryl, alkanoyloxyalkyl or dialkylaminoethyl; Q?1 and Q2¿ are hydrogen, hydroxy or OR3; or, together, oxygen; or Q?1 (Q2) and R1 (R2¿), together, constitute a double bond; or Q?2 and R2¿, with carbon atoms 3 and 4, form an oxetane ring. X is hydrogen; or X and Q1 (Q2), taken together, form a double bond, C24,25-bond is a double or a single bond; one or more of the double bonds optionally being epoxidized or hydrated; and pharmaceutically acceptable salts and in vivo hydrolysable esters thereof. The present compounds are cholesterol-lowering and anti-atherosclerosis agents.</p> |
