| 摘要 |
<p>The present invention concerns aminoacyl and oligopeptidyl derivatives of allopurinol (1,5-dihydro-4H-pyrazolo-[3,4-d]-pyrimidin-4-one) of general formula (I), and related salts with <CHEM> pharmacologically-acceptable cations, in which n is an integer between 2 and 6, preferably 5, Y is H or CO-A, in which A is a racemic or chiral amino acid, dipeptide, tripeptide, tetrapeptide, or pentapeptide chosen, respectively, from the goups consisting of: a) arginine, aspartic acid, lysine, leucine; b) glycylaspartate, glycylglycine, aspartylarginine, leucylarginine, alanylglycine; c) arginyllysylaspartate, aspartyllysylarginine, lysylprolylarginine, prolylprolylarginine, lysylhistidylglycinamide, prolylphenylalanylarginine, phenylalanylprolylarginine; d) arginyllysylaspartylvaline, valylaspartyllysylarginine, threonylvalylleucylhistidine; e) arginyllysylaspartylvalyltyrosine. l</p> |
