| 摘要 |
A thienopyrimidine derivative, wherein it has: (1) a carboxyl group which may be esterified and (2) a group which is capable of forming an anion or a group convertible thereinto except carboxyl group in its molecule, such as a compound of formula (I'), wherein each of R1 and R2 are hydrogen or an optionally substituted hydrocarbon residue, R3 is a C1-6 alkyl group which is substituted by a C1-6 alkoxy-carbonyl group or a group of the formula: -NH-SO2-R5, wherein R5 is : (1) a C1-6 alkyl group which may optionally be substituted by halogen or (2) a C6-14 aryl group, R4 is an optionally substituted hydrocarbon residue or an optionnally substituted heterocyclic group, W denotes a chemical bond or a spacer group and n denotes an integer of 1 to 3; or a salt thereof, exhibits high endothelin receptor antagonist action and can, therefore, be used with advantager as a prophylactic or therapeutic drug for acute renal failure, myocardial infarction, lever disorder, angina pectoris, cerebral infarction, cerebrovasospasm, hypertension, kidney disease, asthma, ectopic angina, Raynaud's syndrome, pulmonary hypertension, surgical shock, chronic heart failure, atherosclerosis, cardiac hyperthrophy, migraine, etc., as a prophylactic or therapeutic drug for organ surgery- or graftassociated hypofunction of organs, as a prophylactic drug for vascular restenosis following percutaneous transluminal coronary angioplasty (PTCA), or as an inhibitor for vasoconstriction of cerebrovascular system or pulmonary vascular system. |
