USE OF A NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR IN ASSOCIATION WITH NUCLEOSIDE INHIBITORS FOR THE TREATMENT OF HIV INFECTION

摘要

The use of a non-nucleoside reverse transcriptase inhibitor is described, in particular of derivatives of 6-benzyl-4-oxopyrimidine having general formula (I), in which X is selected from the group consisting of O, S; R is selected from the group consisting of alkyl from C1 to C4, cycloalkyl C5 and C6; R', R" and Z, equal or different among them may be H, alkyl from C1 to C4 considering that when X is equal to 0, R and R' cannot be both equal to H, their pharmaceutically acceptable salts and their soluble derivatives, in association with nucleoside inhibitors selected from the group consisting of AZT, d4T and their phosphodiester or phosphotriester derivatives, for the treatment of HIV infection. Pharmaceutical compositions useful for the treatment of HIV infection consisting of the association of different components are also described.