| 摘要 |
A process for producing a 1-alkylthio- or 1-arylthiomethanediphosphonate compound by conducting the coupling reaction represented by formula (I) in the presence of a metallic oxide, wherein four R'1 groups represent each independently C1-C6 linear or branched alkyl; four R1 groups represent each independently a pharmacologically acceptable cation, hydrogen or C1-C6 linear or branched alkyl; and R2 represents alkyl or aryl. This process is extremely useful from the economic and industrial points of view, because the yield is remarkably improved and accordingly the purification procedure is simplified as compared with the conventional ones. |
