| 摘要 |
<p>Retroviral vectors are disclosed which are useful in gene therapy. The packageable RNA genome of the vector provides in the DNA provirus a regulated promoter which is inducible by a regulatory factor e.g. the HIV transactivator protein Tat, and at least one selected gene under its transcriptional control. In the DNA provirus, the regulated promoter is present in the 5' long terminal repeat (LTR) in place of the 5'LTR promoter function of the retrovirus, and the selected gene is located between the LTRs. Thus when inserted into a host cell the gene will be expressed only when the DNA provirus is exposed to the regulatory factor.</p> |
