| 摘要 |
<p>Provided are pharmaceutical formulations, and methods of inhibiting fungal and parasitic activity using a compound of formula (I), wherein R', R', R''', R?x1, Rx2, Ry1, Ry2, Ry3, Ry4 and R0¿ are as defined hereinabove; and R2 is (i); R3 is (ii), (iii), (iv) or (v); R?3a, R3b, R3c and R3d¿ are independently hydrogen, C¿1?-12 alkyl, C2-C12 alkynyl, C1-C12 alkoxy, C1-C12 alkylthio, halo, or -O-(CH2)m-[O-(CH2)n]p-O-(C1-C12 alkyl) or -O-(CH2)q-X-R?4¿; m is 2, 3 or 4; n is 2, 3, or 4; p is 0 or 1; q is 2, 3, or 4; X is pyrrolidino, piperidino or piperazino; and R4 is hydrogen, C¿1?-C12 alkyl, C3-C12 cycloalkyl, benzyl or C3-C12-cycloalkylmethyl; or a pharmaceutically acceptable salt thereof.</p> |
