| 发明名称 |
RECOMBINANT HEREGULINS AND THEIR BIOLOGICAL FUNCTIONS UPON RECEPTOR ACTIVATION |
| 摘要 |
Disclosed are generation of versatile recombinant heregulins and some of the biological functions and intracellular signaling pathways that these proteins trigger following receptor activation. Also disclosed is the cloning of the cDNA fragments encoding the EGF-like domain of HRG- alpha , - beta 2 or - beta 3 into an eukaryotic expression vector and the transfection of the vector into mammalian cells. The recombinant heregulins are useful in activating the HER4 receptor.
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| 申请公布号 |
WO9636720(A1) |
申请公布日期 |
1996.11.21 |
| 申请号 |
WO1996US06861 |
申请日期 |
1996.05.14 |
| 申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
CULOUSCOU, JEAN-MICHEL;CARLTON, GARY, W.;ARUFFO, ALEJANDRO, A. |
| 分类号 |
C12N15/09;A61K38/00;A61K38/22;A61P43/00;C07K14/475;C07K14/52;C07K19/00;C12N5/10;C12P21/02;(IPC1-7):C12N15/62;C12N15/12;A61K38/18 |
主分类号 |
C12N15/09 |
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