BIOLOGICALLY ACTIVE POLYMER-BOUND ANTHRACYCLINES, INTERMEDIATE COMPOUNDS, METHODS OF SYNTHESIS, PHARMACEUTICAL COMPOSITION

摘要

FIELD: organic chemistry, polymers. SUBSTANCE: product: polymer-bound anthracyclines consisting of mainly three units of the general formulas (I), (II)and (III)where Gly - glycine; n = 0 or 1; x = 70-98 mole %; y = 1-29 mole %; z = 1-29 mole %; R- C-alkyl-group substituted with one or more hydroxy-groups; Y - amino acid residue or peptide; [NH-"Д"] - residue of anthracycline aminoglycoside [[NH-"D″]-"Д"] and Z - hydroxy-group or residue of the general formula -NHRwhere R- as indicated above. Invention proposes methods of their synthesis and pharmaceutical compositions also. EFFECT: improved method of synthesis.