| 发明名称 |
Urethanes and ureas that induce cytokine production |
| 摘要 |
<p>The invention relates to novel ureas and urethanes of Formula I: <IMAGE> Formula I which stimulate cytokine production and may be used to accelerate recovery from neutropenia accompanying radio- or chemotherapy, bone marrow transplantation, or infections. Compounds in the invention or pharmaceutical compositions employing these compounds may be useful in the treatment of cancer, AIDS, aplastic anemia, myelodysplastic syndrome, and infectious diseases, and in the enhancement of immune response.</p> |
| 申请公布号 |
EP0652228(B1) |
申请公布日期 |
1996.10.23 |
| 申请号 |
EP19940106123 |
申请日期 |
1994.04.20 |
| 申请人 |
AMERICAN CYANAMID COMPANY |
发明人 |
AYRAL-KALOUSTIAN, SEMIRAMIS;SCHOW, STEVEN R.;DU, MILA T.;GIBBONS, JAMES J., JR. |
| 分类号 |
C07D263/06;A61K31/17;A61K31/27;A61K31/325;A61K38/00;A61K38/05;A61P31/12;A61P31/18;A61P35/00;A61P37/04;A61P43/00;C07C237/22;C07C269/04;C07C271/22;C07C271/24;C07C273/18;C07C275/16;C07C275/26;C07K5/02;C07K5/06;C07K5/068;C07K5/072;(IPC1-7):C07K5/06 |
主分类号 |
C07D263/06 |
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