USE OF 2-PHENYL-3-AROYLBENZOTHIOPHENES FOR THROMBODULIN EXPRESSION INCREASE TO INHIBIT THROMBOTIC DISORDER, FOR PROTEIN C ACTIVATION

摘要

FIELD: organic chemistry. SUBSTANCE: product: compound of the formula (I)where Rand Rmean independently hydrogen, -CH,-alkyl) orwhere Ar - optional substituted phenyl; Ris taken form the group involving pyrrolidino-, hexamethyleneimino- and piperidino-group; or its pharmaceutically acceptable salts or solvates. Invention involves also method of thrombotic damage inhibition or administration of effective dose of compound of the formula (I)to patient. Invention involves also method of increase of protein C activation rate that includes administration of compound of the formula (I). EFFECT: improved method of synthesis, enhanced effectiveness.