METHOD OF MODIFICATION, METHOD OF PROVIDING PROTEIN BINDING WITH ANTIBODY, PHARMACEUTICAL COMPOSITIONS, METHOD OF DIAGNOSIS

摘要

FIELD: biology, immunology, pharmacy. SUBSTANCE: invention provides methods of protein (antibody) targeting into intercellular compartments of eucaryotic cell, pharmaceutical compositions of modified proteins for men treatment and methods of modified proteins preparing. Modified proteins of the present invention involve protein bound with lipid in which one or more acyl-groups were bound with protein by side carbohydrate chain and different covalent links. Lipidized antibodies of the present invention can be used for curative and diagnostic aims. EFFECT: improved method of modification and diagnosis.