发明名称 |
THROMBIN INHIBITORS BASED ON THE AMINO ACID SEQUENCE OF HIRUDIN |
摘要 |
A thrombin inhibitor comprising a first bulky hydrophobic portion interacting with the catalytic side of thrombin responsible for proteolysis and a second portion maintaining the hydrophobic and acidic character of amino acids 55 to 60 of native hirudin at the C-terminal non-catalytic region of N-acetyl-hirudin45-65. Between the first and second portions is a divalent linker moiety. The compound is useful in the treatment of thrombotic disorders.
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申请公布号 |
CA2215702(A1) |
申请公布日期 |
1996.09.26 |
申请号 |
CA19962215702 |
申请日期 |
1996.03.18 |
申请人 |
NATIONAL RESEARCH COUNCIL OF CANADA |
发明人 |
DIMAIO, JOHN |
分类号 |
A61K38/00;A61P7/02;C07K7/06;C07K14/815;(IPC1-7):C07K14/815;C07K7/02;A61K38/58 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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