Antisense oligonucleotides having improved cellular uptake, increased nuclease resistance, and thermodynamically more stable target-binding capacity are disclosed. These novel oligonucleotides are characterized by having from 1 to 10 thiono-triester phosphorothioate internucleoside linkages bearing lipophilic moieties.
申请公布号
WO9629337(A1)
申请公布日期
1996.09.26
申请号
WO1996US03843
申请日期
1996.03.22
申请人
HYBRIDON, INC.;ZHANG, ZHAODA;TANG, JIMMY, X.;TANG, JIN, YAN
