| 摘要 |
Intracellular free calcium concentrations are lowered by administering certain dihydropyridine derivatives to cells. Dihydropyridine and other test compounds are screened for their ability to lower intracellular free calcium, particularly by inhibiting the influx of calcium through calcium leak channels, and the identified compounds incorporated into pharmaceutical compositions. Exemplary dihydropyridine derivative compounds include 4-(3-trifluoromethylphenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine; 4-(4-bromophenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine; 4-(4-trifluoromethylphenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine; 4-(4-methylphenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine; and 4-(4-cyanophenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine.
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