| 摘要 |
<p>NEW MATERIAL:A compound (salt) shown by the formula (R is H or lower alkyl). EXAMPLE:N<6>-Benzoyl-2',3'-0-ethoxymethylideneneplanocin A. USE:A carcinostatic agent having inhibitory action on the growth of L 5178Y cell. PROCESS:2',3'-0-Protecting-neplanocin A is reacted with cyanoethylphosphoric acid in an organic solvent such as pyridine, etc. in the presence of a condensation agent such as N,N'-dicyclohexylcarbodiimide, etc. at a temperature preferably <= room temperature. The 2',3'-0-protecting group of the prepared 2',3'- 0-protecting-neplanocin A-5'-cyanoethylphosphate is eliminated, the resultant compound is terated with an alkali so that the cyanoethyl group is removed, to give the desired compound.</p> |
