INCREASED BIOAVAILABILITY OF BIOLOGICALLY ACTIVE COMPOUNDS BY LINKING TO POLYPYRROLECARBOXAMIDONAPHTHALENE DERIVATIVES
摘要
A compound of formula (II) wherein R is an acidic group; m is an integer of 1 to 3; n is zero or an integer of 1 to 3; A is an enzymatically hydrolyzable spacer; and X is a biologically active compound; or a pharmaceutically acceptable salt thereof, for use as an antiproliferative, in particular anti-tumor and anti-angiogenic agent, and anti-inflammatory agent, is provided.
申请公布号
WO9626950(A1)
申请公布日期
1996.09.06
申请号
WO1996EP00528
申请日期
1996.02.08
申请人
PHARMACIA S.P.A.;MONGELLI, NICOLA;BIASOLI, GIOVANNI;LOMBARDI BORGIA, ANDREA;CIOMEI, MARINA;PESENTI, ENRICO;ANGELUCCI, FRANCESCO
发明人
MONGELLI, NICOLA;BIASOLI, GIOVANNI;LOMBARDI BORGIA, ANDREA;CIOMEI, MARINA;PESENTI, ENRICO;ANGELUCCI, FRANCESCO