| 摘要 |
NEW MATERIAL:An aconitine compound shown by formula I (R1 is benzoyl or anisoyl; R2 is methyl or ethyl; with the proviso that when R1 is benzoyl, R2 is methyl and when R1 is anisoyl, R2 is ethyl). EXAMPLE:3-Acetylmesaconitine. USE:Having stronger analgesic action than morphine, analgesic action not being affected by narcotic antagonist even by using the compound together with narcotic antagonist, useful as analgesic and anti-inflammatory drug. PREPARATION:Hydroxyl group at the 3-position of mesaconitine shown by formula II or diesaconitine shown by formula III is reacted with an acetylating agent such as acetic anhydride in a proper solvent and acetylated to give a compound shown by formula I.
|
