发明名称 |
Multiple oligonucleotide containing oligomers and the cleanable linkers used in their preparation |
摘要 |
A method for the synthesis of a plurality of oligonucleotides comprising the steps of (i) forming a first oligonucleotide on a first cleavable link attached to a solid support; (ii) attaching to the first oligonucleotide a cleavable linker moiety; (iii) forming a second oligonucleotide on the cleavable linker moiety; and (iv) cleaving the first cleavable link and the cleavable linker moiety to give a plurality of oligonucleotides; wherein the cleavable linker moiety is of the Formula (1): <IMAGE> (1) in which A1, A2 and E are as defined herein, and novel compounds which may be used in the operation of the method.
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申请公布号 |
US5552535(A) |
申请公布日期 |
1996.09.03 |
申请号 |
US19940337025 |
申请日期 |
1994.11.07 |
申请人 |
ZENECA LIMITED |
发明人 |
MCLEAN, MICHAEL J.;HOLLAND, DAVID;GARMAN, ANDREW J.;SHEPPARD, ROBERT C. |
分类号 |
C12N15/09;C07F9/655;C07H21/00;C07H21/04;(IPC1-7):C07H21/00;C07F9/02;C07D333/00;C07C69/66 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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