| 摘要 |
The instant invention provides for monoclonal antibody which is specific for the beta A4 peptide, and in particular the free C-terminus of beta A4 "1-42" but not "1-43", and stains diffuse and fibrillar amyloid, vascular amyloid, and neurofibrillary tangles. The instant invention further provides for antibody fragments and constructs thereof which have the same binding specificity. The instant invention also provides for methods of diagnosis, screening and therapeutics for treating unique forms of beta A4 peptide, using the antibodies of the instant invention.
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