| 发明名称 |
Muteins of human epidermal growth factor exhibiting enhanced binding at low PH |
| 摘要 |
EGF muteins in which the histidine at position 16 is replaced with a neutral or acidic amino acid exhibit activity at pHs lower than obtainable with wild type EGF.
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| 申请公布号 |
US5547935(A) |
申请公布日期 |
1996.08.20 |
| 申请号 |
US19940284923 |
申请日期 |
1994.08.02 |
| 申请人 |
CHIRON CORPORATION |
发明人 |
MULLENBACH, GUY T.;BLANEY, JEFFREY M.;ROSENBERG, STEVEN |
| 分类号 |
A61K38/00;C07K14/485;C12N15/18;(IPC1-7):C12N15/18;A61K38/18 |
主分类号 |
A61K38/00 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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