发明名称 |
PREPARATION AND USE OF NOVEL CYCLODEXTRIN-BASED DISPERSIBLE COLLOIDAL SYSTEMS IN THE FORM OF NANOSPHERES |
摘要 |
PCT No. PCT/FR93/00594 Sec. 371 Date Mar. 8, 1995 Sec. 102(e) Date Mar. 8, 1995 PCT Filed Jun. 16, 1993 PCT Pub. No. WO93/25195 PCT Pub. Date Dec. 23, 1993A nanoparticulate system prepared by: 1) preparing a liquid phase essentially consisting of a solution of cyclodextrin modified by acyl groups in an organic solvent or solvent mixture, an active molecule being optionally added thereto; 2) preparing a second liquid phase essentially consisting of water or an aqueous mixture optionally containing one or more surfactants, and optionally having an active molecule added thereto; and 3) gently stirring one of the liquid phases resulting from 1) or 2) into the other in order to obtain, almost instantaneously, a colloidal solution of modified cyclodextrin nanospheres. If required, all or part of the solvent and all or part of the water may be removed. The system may be used as a carrier for pharmaceuticals, cosmetics, chemicals, etc. |
申请公布号 |
EP0646003(B1) |
申请公布日期 |
1996.08.14 |
申请号 |
EP19930913149 |
申请日期 |
1993.06.16 |
申请人 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) |
发明人 |
SKIBA, MOHAMED;WOUESSIDJEWE, DENIS;COLEMAN, ANTONY;FESSI, HATEM;DEVISSAGUET, JEAN-PHILIPPE;DUCHENE, DOMINIQUE;PUISIEUX, FRANCIS |
分类号 |
A61J3/07;A61K8/04;A61K8/73;A61K9/51;A61K47/40;A61Q19/00;B01J13/00;B01J13/04;B01J13/08;(IPC1-7):A61K9/51 |
主分类号 |
A61J3/07 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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