发明名称 Synthetic compounds which bind to H. pylori, and uses thereof
摘要 The present invention provides a compound having the structure: <IMAGE> +TR <IMAGE> wherein A is selected from the group consisting of (i) an amino acid bearing an omega -amino group or an omega -(C=O)- group, (ii) an amino acid residue of a peptide, which residue bears an omega -amino group or an omega -(C=O)- group, and (iii) an amino acid residue of a protein, which residue bears an omega -amino group or an omega -(C=O)- group; wherein R1 is H, OH, NH2 or NHR4, where R4 is SO2Ph, a linear or branched chain alkyl or acyl group, or an aryl group; wherein M is a saccharide wherein n is an integer from 0 to 18, and where n is greater than 1, each M is independently the same or different; wherein p is either 0 or 1; wherein R2, R3, R5 and R6 are independently the same or different and are H or OH, with the proviso that R2 and R3 are not both OH, and R5 and R6 are not both OH; wherein X and Y are independently the same or different and are H2 or O; and wherein k is an integer greater than or equal to 1, with the proviso that when A is an amino acid bearing an omega -amino group or an omega -(C=O)- group, k is equal to 1.
申请公布号 US5543505(A) 申请公布日期 1996.08.06
申请号 US19930213053 申请日期 1993.03.15
申请人 SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH 发明人 DANISHEFSKY, SAMUEL J.;RANDOLPH, JOHN T.
分类号 A61K38/00;C07H3/06;C07H17/04;C07K9/00;C07K14/765;(IPC1-7):C07H15/00;C07H15/06;C07H17/00;C07K1/00 主分类号 A61K38/00
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