Long-acting drug formulation containing pyrimidinedione derivatives

摘要

Treatment of arrhythmia requires administration of an antiarrhythmic drug over a long period of time. A long-acting drug formulation for oral administration, which is safe and effective for the treatment of arrhythmia, has been provided. This long-acting antiarrhythmic formulation comprises at least one unit I and at least one unit II. The unit I comprises as an effective ingredient a pyrimidinedione derivative having antiarrhythmic action and represented by the following formula (1): and promptly releases the effective ingredient in the stomach. On the other hand, the unit II is composed of a core, which comprises the same effective ingredient, and an enteric coat surrounding the core. The unit II promptly releases the effective ingredient in the small intestine.