发明名称 |
Stabilization of aminosteroids for topical ophthalmic and other applications |
摘要 |
The invention provides methods for stabilizing amino-substituted steroid therapeutic agents in topical ophthalmic and other pharmaceutical formulations using effective stabilizing amounts of lightly cross-linked carboxy-containing polymers; and methods for stabilizing and solubilizing amino-substituted steroid therapeutic agents in such pharmaceutical formulations using effective stabilizing amounts of lightly cross-linked carboxy-containing polymers and amounts of selected cyclodextrin derivatives sufficient to at least partially solubilize the therapeutic agents. The cyclodextrin derivatives are selected from the group consisting of the hydroxypropyl, hydroxyethyl, glucosyl, maltosyl and maltotriosyl derivatives of beta - and gamma -cyclodextrin. Stabilized and stabilized/solubilized pharmaceutical compositions adapted for various routes of administration are also described.
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申请公布号 |
US5538721(A) |
申请公布日期 |
1996.07.23 |
申请号 |
US19940202469 |
申请日期 |
1994.02.28 |
申请人 |
INSITE VISION INCORPORATED |
发明人 |
BABCOCK, JOHN C.;POLANSKY, JON R.;BOWMAN, LYLE M.;TSAO, SHENG-WAN;SI, ERWIN C. C.;CHANDRASEKARAN, SANTOSH K. |
分类号 |
A61K9/107;A61K9/00;A61K9/127;A61K31/56;A61K31/58;A61K38/08;A61K47/48;A61P27/02;C07J41/00;(IPC1-7):A61K31/74;A61K47/28 |
主分类号 |
A61K9/107 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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