摘要 |
PCT No. PCT/FR95/01697 Sec. 371 Date Nov. 5, 1997 Sec. 102(e) Date Nov. 5, 1997 PCT Filed Dec. 19, 1995 PCT Pub. No. WO96/19237 PCT Pub. Date Jun. 27, 1996Vaccines, composed of antigens absorbed on alum or formulated in an alum-containing composition, have enhanced immunogenicity over existing vaccines. The vaccines of the invention are characterized by their combination with 2-120 mu g per kg or 0.1 to 6 mg by dose, preferentially 6-60 mu g per kg or 0.3 to 3 mg per dose, of a hydrosoluble muramyl peptide. |