WAY OF RECEPTION OF MICROSPHERES LABELED WITH RADIONUCLIDE

摘要

FIELD: medicine. ^ SUBSTANCE: invention concerns a way of reception of radioactive microspheres and can be used for reception of radiodrugs for radionuclide therapy of malignant neoplasms. The way of reception labelled a radionuclide of microspheres includes an emulsification of a solution of an albumin in vegetable oil, the further thermal processing of an emulsion and its filtration. Thus stable isotope Pd and a radionuclide 103Pd, in the form of a chloride palladium in 0.1 M a hydrochloric acid solution are admixed with albumin microspheres. The received admixture is processed with ultrasound before reception of homogeneous suspension then it is maintained at a room temperature within 18-24 hours. Microspheres are allocated from an admixture with a centrifugation with the subsequent restoration by Hydrosodium sulfitum. Fraction of microspheres with a diametre 20-40 micron is used. ^ EFFECT: reception of microspheres of an albumin with high specific activity. ^ 2 ex, 1 tbl