Novel Substituted Quinoline Compounds as S-Nitrosoglutathione Reductase Inhibitors

摘要

The present invention is directed to novel quinoline compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.

主权项

1. A method of inhibiting the activity of the enzyme S-nitrosoglutathione reductase (GSNOR) comprising the step of contacting said enzyme with a compound of formula I: wherein m is selected from the group consisting of 0, 1, 2, or 3; R1 is independently selected from the group consisting of chloro, fluoro, bromo, cyano, and methoxy; R2b and R2c are independently selected from the group consisting of hydrogen, halogen, C1-C3 alkyl, fluorinated C1-C3 alkyl, cyano, C1-C3 alkoxy, and N(CH3)2; X is selected from the group consisting ofn is selected from the group consisting of 0, 1, and 2;
R3 is independently selected from the group consisting of halogen, C1-C3 alkyl, fluorinated C1-C3 alkyl, cyano, C1-C3 alkoxy, and NR4R4′ where R4 and R4′ are independently selected from the group consisting of C1-C3 alkyl, or R4 when taken together with R4′ form a ring with 3 to 6 members; and A is selected from the group consisting of or a pharmaceutically acceptable salt, stereoisomer, or N-oxide thereof.