发明名称 |
ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY |
摘要 |
A compound represented by general formula (1),zor possible stereoisomers and optical isomers thereof, and medicinally acceptable salts of these, (wherein R1 represents SR6 or NR7R8; R6 represents C1-C6 alkyl, etc.; R7 represents hydrogen, C1-C6 alkyl or nitro; R8 represents hydrogen or C1-C6 alkyl; R2 and R3 represent each hydrogen, C1-C6 alkyl, etc.; R<4> represents hydrogen, C1-C6 alkyl or amidino wherein the amine moiety may be substituted by alkyl or nitro; R5 represents hydrogen or C1-C6 alkyl; Y1, Y2, Y3 and Y4 may be the same or different and each represents hydrogen, halogeno, C1-C6 alkoxy, etc.; and n and m represent each an integer of 0 or 1). The compound has a potent nitrogen monoxide synthase inhibitory activity and is useful as a remedy for cerebrovascular disorder. |
申请公布号 |
WO9618608(A1) |
申请公布日期 |
1996.06.20 |
申请号 |
WO1995JP02540 |
申请日期 |
1995.12.12 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA;HONDA, TOSHIO;MAKINO, TOSHIHIKO;NAGAFUJI, TOSHIAKI;KITOH, YASUSHI;KIMURA, NOBUAKI |
发明人 |
HONDA, TOSHIO;MAKINO, TOSHIHIKO;NAGAFUJI, TOSHIAKI;KITOH, YASUSHI;KIMURA, NOBUAKI |
分类号 |
C07D295/12;A61K31/155;A61K31/195;A61K31/21;A61K31/215;A61K31/27;A61K31/275;A61K31/40;A61P3/00;A61P3/14;A61P9/00;A61P43/00;C07C57/30;C07C205/11;C07C205/12;C07C205/19;C07C205/37;C07C205/56;C07C211/52;C07C211/53;C07C271/10;C07C279/18;C07C279/30;C07C279/34;C07C279/36;C07C335/16;C07C335/20;C07C335/22;C07C335/32;C07C335/36;C07C381/14;C07D209/48;C07D295/135 |
主分类号 |
C07D295/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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